Biol. Pharm. Bull. 30(8) 1461—1467 (2007)
نویسندگان
چکیده
metalloproteinases and tissue inhibitors of matrix metalloproteinases at multiple levels of regulation. Retardation of wound healing is one of complications in diabetes mellitus due to increased collagenase activity and reduced granulation tissue in the diabetic wound. Studies on wound healing in streptozotocin (STZ)-induced diabetic rats suggested the possibility that the reduced breaking wound strength is due to the increased activity of collagenase, which is a member of the MMP family which includes gelatinase and stromelycin. Although it is plausible that inhibition of the accelerated destructive activity of MMPs improves wound healing, the role of MMPs in wound healing has not been fully elucidated yet. To investigate the effects of MMP inhibitors (MMPIs) on wound healing in STZ-induced diabetic rats, we used newly synthesized MMPIs, FYK-1388, FYK-1352 and F61-1008. These compounds have a strong and broad MMP inhibitory activity. Contrary to our anticipation, these MMPIs did not stimulate wound healing in STZ-induced diabetic rats. In the course of our study, unexpected reducing effects on serum triacylglycerol (TG) in STZ-induced diabetic rats and Zucker fa/fa rats were found with these MMPIs. The hypolipidemic effect of these MMPIs is striking and has not been reported until now. We report our results here.
منابع مشابه
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